Computer Aided Decision Support System Pdf

Computer aided decision support system pdf

Objective To assess the effectiveness of computer-aided clinical decision support systems CDSS in improving antibiotic prescribing in primary care. Randomized controlled trials RCTs and cluster randomized trials CRTs that evaluated the effects of CDSS aiming at improving antibiotic prescribing practice in an ambulatory primary care setting were included for review.

Two investigators independently extracted data about study design and quality, participant characteristics, interventions, and outcomes.

1. Introduction

All studies were performed in the USA. Proportions of eligible patient visits that triggered CDSS use varied substantially between intervention arms of studies range 2. Five out of seven trials showed marginal to moderate statistically significant effects of CDSS in improving antibiotic prescribing behavior. CDSS that automatically provided decision support were more likely to improve prescribing practice in contrast to systems that had to be actively initiated by healthcare providers.

Conclusions CDSS show promising effectiveness in improving antibiotic prescribing behavior in primary care. Magnitude of effects compared to no intervention, appeared to be similar to other moderately effective single interventions directed at primary care providers.

Additional research is warranted to determine CDSS characteristics crucial to triggering high adoption by providers as a perquisite of clinically relevant improvement of antibiotic prescribing. Medical decision-making is a highly complex and contextually dependent process.

Practice guidelines synthesize the best available evidence and support decision-making by clinicians about the organization and delivery of healthcare. However, non-adherence of healthcare practitioners to guidelines is common and there are intensive efforts to promote evidence-based decision-making in a range of clinical settings.

Introduction to Decision Support Systems

CDSS have been shown to be effective in the improvement of provider performance across various clinical settings. A systematic review of studies on various types of clinical decision support systems used to support evidence-based antibiotic prescribing published by Shebl et al. However, the vast majority of antibiotics are prescribed in primary care 22 and there is broad agreement that it is in the primary healthcare sector that one can achieve the greatest decrease in the total use of these medications.

The aim of the present systematic review of RCTs and cluster-randomized trials CRTs is to evaluate the recent progress of CDSS as a tool to improve antibiotic prescribing in primary care.

Decision support system

Medline via PubMed and Embase via Embase were searched from inception to November see online supplementary material 1 for search strategies.

Reference lists of relevant articles were inspected to identify additional articles that could have been missed by our search strategy.

No language restrictions were applied. We did not contact experts for relevant studies.

Computer aided decision support system pdf

For consideration in this systematic review the following inclusion criteria were applied to each publication: healthcare providers in outpatient settings; the intervention contained a computer-aided CDSS aiming at improving antibiotic prescribing practice and was compared to an intervention that contained a different computer-aided CDSS, any other intervention, or no intervention.

For inclusion, the outcome of the study had to be any measure of antibiotic prescription. Studies that analyzed antibiotics among others drugs, had to incorporate subgroup analyses for antibiotics. All titles and abstracts were screened independently by two members of the research team; the full texts of potentially eligible articles were then obtained and further assessed for eligibility against the review inclusion criteria.

Data were extracted by one reviewer into structured summary tables and checked for accuracy by a second reviewer. Assessment of methodological quality of the eligible studies was undertaken independently by two reviewers. We applied the Cochrane risk of bias tool to assess the quality of the included RCTs.

Decision Support Systems

We also expected to include CRTs. There are specific methodological issues that are relevant for CRTs. High study heterogeneity was expected because of the diversity of CDSS interventions, variations of studied outcomes, and different populations. Thus, a quantitative data synthesis using a meta-analysis was not planned a priori. Study results were considered statistically significant if the p value was below 0.

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The search strategy generated hits. In the title and abstract screening, 37 studies were included for detailed evaluation. A total of 30 studies did not meet inclusion criteria. Eight of these were excluded because they did not investigate CDSS. Five studies were not conducted in the outpatient setting. Another five studies did not analyze antibiotic prescribing, 10 were not RCTs or CRTs, and for two studies the full text was unavailable.

In total, seven studies 21 , 24 , 26—30 met our inclusion criteria see figure 1.


Flow chart of literature search and study selection. Online supplementary material 2 lists excluded studies, along with the reasons for exclusion. The number of analyzed providers varied from 28 to in the RCTs, while the number of analyzed clusters varied from 12 to 33 clusters, including a range of to providers in the CRTs.

Study characteristics and outcomes of included trials are shown in supplementary material 3. All studied tools were integrated either into a preexisting electronic health record 21 , 26 , 28—30 or into an electronic prescription writer, 24 , 27 rather than operating as a stand-alone system.

Computer aided decision support system pdf

None of the CDSS demanded mandatory response or justification in case recommendations were not followed. The studies focused on a wide range of conditions.

However, two studies dealt exclusively with otitis media in children, and the reported information of a third trial allowed only for the extraction of data on antibiotic prescriptions to treat pediatric otitis media.

The risk of bias of the included studies was difficult to assess. In all but one study the majority of items were judged to have an unclear risk of bias 27 see table 1. In many instances this was a result of insufficient reporting in the trials.

Computer aided decision support system pdf

Overall five out of seven trials showed significant effects in improving antibiotic prescribing behavior see supplementary material 3.

In a study by Christakis et al.

Computer aided decision support system pdf

Prompts were delivered once a provider entered an antibiotic prescription into an electronic prescription writer. The CDSS did not impact prescription rates for otitis media. However, as mentioned above, data on antibiotic prescriptions could only be extracted for otitis media visits.

A small proportion of the data on otitis media were already included in the report by Christakis et al. Similar to the former tool the CDSS under study provided evidence based prompts at the point-of-care. Antibiotic prescribing for otitis media in contrast to baseline data increased in both study arms, but significantly less in the intervention group.

Results were reported separately for two intervention sites. Forrest et al.

Biomedical Informatics for Computer-Aided Decision Support Systems: A Survey

Among other components it included tools for data entry, and cognitive aids that gather, organize, and display information.

A subset of five out of eight domains directly concerned antibiotic prescribing practice in the treatment of AOM four domains and OME one domain. In accordance with practice guidelines, providers in the intervention arm were significantly more likely to choose amoxicillin as a first-line treatment of AOM 4. No significant effects were observed with regard to adequate dosing of antibiotic treatment of AOM, adequate choice of an antibiotic to treat penicillin-allergic patients, and overall reductions of antibiotic prescribing in the treatment of AOM and OME.

Four additional studies assessed the effects of CDSS on the reduction of antibiotic prescription as a primary outcome.

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In contrast, McGinn et al. In this study an integrated clinical prediction rule was used to enable providers to complete risk score calculators, order medications, and generate progress notes to assist with decision-making at the point of care.

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No age group restrictions for the inclusion of patients were reported. Gonzales et al.

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The CDSS integrated a structured template for documenting relevant history and physical examination elements which served as a basis to ascertain the probability that a patient had pneumonia. We systematically reviewed the evidence for the effectiveness of CDSS aiming to improve antibiotic prescribing behavior among primary care providers.

In recent years several systematic reviews have been published, either assessing the effectiveness of a broad set of interventions including CDSS to optimize antibiotic prescribing in primary care, 31—33 or appraising effects of various clinical decision support systems on antibiotic prescribing in the inpatient and outpatient setting.

Hence, for the first time, a relevant number of trials assessing the impact of CDSS on antibiotic prescribing in primary care were reviewed. Our review provides evidence that CDSS can increase the appropriateness of antibiotic treatment in the outpatient setting. With five out of seven trials the majority of included studies improved antibiotic prescribing among healthcare practitioners to some extent.

While the effects of the two remaining trials were not statistically significant, the results of both trials were slightly in favor of CDSS. Overall, successful trials showed that CDSS had statistically significant slight to moderate effects in increasing the appropriateness of antibiotic treatment compared to no intervention. In terms of reducing antibiotic prescription, three studies showed significant effects.

In the former study, despite absolute reductions, the majority of patients with acute bronchitis in the intervention arm were still treated with antibiotics, which was likely to be inappropriate in most cases. Data regarding durability of effects beyond a 1-year follow-up were provided by two trials. Davis et al.

CDSS use and effects increased throughout the study period. Although this limited information suggests that intervention effects do not fade out over time, more research is needed to assess long-term CDSS utilization and effectiveness. None of the included studies provided information on the durability of effects once the intervention is withdrawn.

Due to heterogeneity of studied conditions, interventions, and outcome measures, estimation of pooled effects was not justified. Considering the limited number of included trials and heterogeneity of studied conditions, CDSS tools, and outcomes putting CDSS effects into a broader context of previous studies to improve antibiotic prescribing in primary care is not a straightforward matter.

Nevertheless, when cautiously examined in contrast to the findings of previous reviews 31 , 32 of interventions to foster appropriate antibiotic treatment, the magnitude of effects of CDSS in contrast to no intervention, appears to be roughly similar to other moderately effective single interventions directed at primary care providers, such as audit and feedback, some forms of clinical education, and clinical decision support in general.

Likewise, in the study by Gonzales et al. Nevertheless, moderate improvements of antibiotic prescribing might not reduce the incidence of resistant pathogens in the community.

Beyond the promising potential of CDSS as a relevant component of more complex approaches, 36 the applicability of single interventions outside the research setting might be higher, due to more favorable cost—benefit profiles. All observations made here have to be viewed as a cautious interpretation of the reviewed data for several reasons.

First, the comprehensive assessment of risk of bias was frequently hampered by insufficient reporting. Overall, for most studies the majority of assessed items were judged to have an unclear risk of bias. Given that in most of the included trials providers and clusters were presumably randomized at once, failure to conceal the allocation sequence was unlikely to be an issue.

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Nevertheless, most studies lacked the information necessary to assess this risk of bias. Second, beyond the unclear risks of bias with regard to most of the a priori specified items for the assessment of study quality, additional biases might have been present. While contamination was likely to be an issue in two studies, 24 , 27 this form of bias, in general, cannot be excluded for studies that randomized healthcare providers.

Furthermore, diagnosis-related bias, that is, the differential tendency between study arms towards coding consistent with a given treatment might frequently be of relevance, where interventions aim at improving diagnosis-specific provider performance.