Lupus Sistemico Eritematoso Pdf Viewer

Lupus sistemico eritematoso pdf viewer

Se han identificado locus que promueven lupus en ratones, se designan Sle1, Sle2 y sle3. Systemic lupus erythematosus SLE is an autoimmune disease in which organs, tissues and cells are damaged by immune complexes. Loci have been identified which promote lupus in mice, are designated Sle1, sle3 and SLE2. Apoptotic cells were initially associated with SLE, when it was shown that SLE autoantigen concentrated within and on the surface of apoptotic cells granules, involving the apoptotic cell as a source of antigens.

Among the autoantibodies that bind apoptotic cells are: anticromatina and phospholipid. Furthermore, antigens in the apoptotic bodies undergo post translational modifications which could result in the production of important antigens. There is enough evidence to say that apoptotic cells are not immunologically neutral, but, depending on the microenvironment in which the process is carried out, presenting cell type and besides the presence or absence of danger signals, these are tolerogenic, or immunogenic.

The immune system uses to eliminate apoptosis of autoreactive B-cell clones and T so that defects in this system contribute to the persistence of these clones and could cause autoimmune diseases.

Scl-3 gene has a role in the control of apoptosis, accelerates the LES, and also activates dendritic cells, with increased secretion of pro-inflammatory cytokines. In patients with SLE observed an increased number of apoptotic cells.

It has been demonstrated that the balance of TNF-alpha and its soluble inhibitor is altered in favor of the latter active lupus, this supports the idea that the decreased activity of TNF-alpha is associated with increased activity in nephritis. Serum levels of IL are elevated in patients with lupus and correlate with activity; serum alpha interferon also are elevated in SLE patients..

Su prevalencia en Estados Unidos es de 15 a 50 por , habitantes; es mayor en personas de ascendencia africana.

Lupus sistemico eritematoso pdf viewer

Se sabe que alelos sin aparente rol de actividad pueden causar deficiencias de uno de los componentes iniciales del sistema del complemento C1q, C2 o C4 y son un importante factor de riesgo para lupus. Berden et al. Estos inmunocomplejos activan el sistema del complemento, lo que da inicio a la glomerulonefritis. Esta serie de eventos han sido demostrados en modelos animales Este proceso es reconocido por el receptor de FS, R-FS, de gran importancia en las fases tempranas de la apoptosis 37, El rol del TNF-alfa en lupus es controvertido, esta citocina puede ser protectora en ellos.

En algunas pacientes con artritis reumatoide que han sido tratadas con anticuerpos anti-TNF alfa desarrollaron anticuerpos anti-DNA de doble cadena y algunos desarrollaron lupus.

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Lupus sistemico eritematoso pdf viewer

Issue 1. Pages January Systemic lupus erythematosus pathophysiology. Download PDF. This item has received. Article information. Palabras clave:. Serum levels of IL are elevated in patients with lupus and correlate with activity; serum alpha interferon also are elevated in SLE patients.

Lupus sistemico eritematoso pdf viewer

Lupus erythematosus; Autoimmune; Autoantigens; Apoptosis; Mexico. Citocinas y lupus El rol del TNF-alfa en lupus es controvertido, esta citocina puede ser protectora en ellos. Conflicto de intereses La autora declara no tener conflicto de intereses.

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Systemic lupus erythematosus (SLE) - causes, symptoms, diagnosis & pathology

Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo..

J Clin Invest. Glomerular apoptotic nucleosomes are central targetstructures of nephritogenic antibodies in human SLE nephritis.. Kidney Int.

Nephritogenic lupus antibodies recognize glomerular basement membrane-associates chromatin fragments released from apoptotic intraglomerular cells..

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Lupus sistemico eritematoso pdf viewer

Immunosuppressive effects of apoptotic cells.. Polyamine regulation of plasma membrane phospholipid flip-flop during apoptosis..

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J Biol Chem. A receptor for phosphatidylserine-specific clearance of apoptotic cells.. Phosphatidylserine induces PS receptor mediated macropinocytosis and promotes clearance of apoptotic cells.. J Cell Biol.

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.. Intracellular trafficking and surface expression of SS-A ro , SS-B La , poly ADP-ribose polymerase and alphafodrin autoantigens during apoptosis in human salivary gland cells induced by tumor necrosis factor-alpha..

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Lupus sistemico eritematoso pdf viewer

Apoptotic modifications affect the autoreactivity of the U1 snRNP autoantigen..