Se han identificado locus que promueven lupus en ratones, se designan Sle1, Sle2 y sle3. Systemic lupus erythematosus SLE is an autoimmune disease in which organs, tissues and cells are damaged by immune complexes. Loci have been identified which promote lupus in mice, are designated Sle1, sle3 and SLE2. Apoptotic cells were initially associated with SLE, when it was shown that SLE autoantigen concentrated within and on the surface of apoptotic cells granules, involving the apoptotic cell as a source of antigens.
Among the autoantibodies that bind apoptotic cells are: anticromatina and phospholipid. Furthermore, antigens in the apoptotic bodies undergo post translational modifications which could result in the production of important antigens. There is enough evidence to say that apoptotic cells are not immunologically neutral, but, depending on the microenvironment in which the process is carried out, presenting cell type and besides the presence or absence of danger signals, these are tolerogenic, or immunogenic.
The immune system uses to eliminate apoptosis of autoreactive B-cell clones and T so that defects in this system contribute to the persistence of these clones and could cause autoimmune diseases.
Scl-3 gene has a role in the control of apoptosis, accelerates the LES, and also activates dendritic cells, with increased secretion of pro-inflammatory cytokines. In patients with SLE observed an increased number of apoptotic cells.
It has been demonstrated that the balance of TNF-alpha and its soluble inhibitor is altered in favor of the latter active lupus, this supports the idea that the decreased activity of TNF-alpha is associated with increased activity in nephritis. Serum levels of IL are elevated in patients with lupus and correlate with activity; serum alpha interferon also are elevated in SLE patients..
Su prevalencia en Estados Unidos es de 15 a 50 por , habitantes; es mayor en personas de ascendencia africana.
Se sabe que alelos sin aparente rol de actividad pueden causar deficiencias de uno de los componentes iniciales del sistema del complemento C1q, C2 o C4 y son un importante factor de riesgo para lupus. Berden et al. Estos inmunocomplejos activan el sistema del complemento, lo que da inicio a la glomerulonefritis. Esta serie de eventos han sido demostrados en modelos animales Este proceso es reconocido por el receptor de FS, R-FS, de gran importancia en las fases tempranas de la apoptosis 37, El rol del TNF-alfa en lupus es controvertido, esta citocina puede ser protectora en ellos.
En algunas pacientes con artritis reumatoide que han sido tratadas con anticuerpos anti-TNF alfa desarrollaron anticuerpos anti-DNA de doble cadena y algunos desarrollaron lupus.
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Issue 1. Pages January Systemic lupus erythematosus pathophysiology. Download PDF. This item has received. Article information. Palabras clave:. Serum levels of IL are elevated in patients with lupus and correlate with activity; serum alpha interferon also are elevated in SLE patients.
Lupus erythematosus; Autoimmune; Autoantigens; Apoptosis; Mexico. Citocinas y lupus El rol del TNF-alfa en lupus es controvertido, esta citocina puede ser protectora en ellos. Conflicto de intereses La autora declara no tener conflicto de intereses.
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